黄路芬

黄路芬博士

黄路芬，副教授，博士毕业于澳门科技大学中药学专业

研究方向：中药免疫药理及药物不良反应机制研究

个人简介：世界中联中医药免疫专业委员会理事，古代经典名方临床研究专业委员会理事。主要从事中药抗风湿活性、中药干预糖尿病机制及药物安全性评价研究。主持和参与课题共10余项，以第一作者发表SCI论文5篇，累计影响因子14.88，发明专利1项。

代表性成果：

一、主持承担的项目

1.广东省医学科学技术研究基金项目；B2018120；Exosomes mciroRNA-155 作为生物标志物预警肥胖人群糖尿病患病风险的研究；2018/7/1-2020/6/30；结题

2.山东省中医药科技发展计划项目；2020M080；基于数字化知识网络和生物学功能的中医药古籍文献发掘整理及其防控痴呆的应用研究；2021/03/1-2023/3/1；在研

3.济宁医学院博士启动基金；肥大细胞膜稳定剂对抗风湿药青藤碱的“减毒增效”作用机制研究，2019/6/15-2024/6/15；在研

4.济宁医学院青年教师科研扶持基金；甘草查尔酮A阻断青藤碱诱导的组织胺释放样过敏反应的机理研究；2020/1/1-2022/12/31；在研

二、代表性论文

1.Lufen Huang, Ting Li, Hua Zhou, Ping Qiu, Jianlin Wu, Liang Liu. Sinomenine potentiates degranulation of RBL-2H3 basophils via up-regulation of phospholipase A2 phosphorylation by Annexin A1 cleavage and ERK phosphorylation without influencing on calcium mobilization;InternationalImmunopharmacology;28(2):945-951. (2015)

2.Lufen Huang, Jiang Pi, Jianlin Wu, Hua Zhou, Jiye Cai, Ting Li, Liang Liu. A rapid and sensitive assay based on particle analysis for cell degranulation detection in basophils and mast cells; Pharmacological Research; 111:374-83. (2016).

3. Lufen Huang, Jiang Pi, Fen Yang, Jinhuan Jiang, Hua Jin, Jianxin Liu, Xiaohui Su, Anguo Wu, Huaihong Cai, Peihui Yang, Jiye Cai. Atomic force microscopy study of ionomycin induced degranulation in RBL-2H3 cells; Scanning; 9999:1-10. (2016).

4.Rui Wang, Jiang Pi, Xiaohui Su, Juan Liu, Xing Zeng, Ivan Wong, Lufen Huang, Hua Zhou, Jiye Cai, Ting Li, Liang Liu Dihydromyricetin suppresses inflammatory responses in vitro and in vivo through inhibition of IKK-beta activity in macrophages; Scanning; 38(6): 901-912. (2016).

5.Lufen Huang, Yan Dong, Jianlin Wu, Peixun Wang, Hua Zhou, Ting Li, Liang Liu. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via nhibiting NF-κB signaling. Pharmacological Research, 2017. 125(Part B): p. 150-160.

6.Su X, Li T, Liu Z, Huang Q, Liao K, Ren R, Lu L, Qi X, Wang M, Chen J, Zhou H, Leung EL-H, Pan H, Liu J, Wang H, Huang L and Liu L Licochalcone A activates Keap1-Nrf2 signaling to suppresses arthritis via phosphorylation of p62 at serine 349. Free Radical Biology and Medicine. 115(1):471-483(2018).

7.Wang J, Huang L, Ren Q, et al. Polysaccharides of Scrophularia ningpoensis Hemsl.: Extraction, Antioxidant, and Anti-Inflammatory Evaluation[J]. Evidence-Based Complementary and Alternative Medicine, 2020, 2020